CALL FOR PAPERS Small Vessels–Big Problems: Novel Insights into Microvascular Mechanisms of Disease Metabolic syndrome impairs reactivity and wall mechanics of cerebral resistance arteries in obese Zucker rats
نویسندگان
چکیده
Steven D. Brooks,* Evan DeVallance,* Alexandre C. d’Audiffret, Stephanie J. Frisbee, Lawrence E. Tabone, Carl D. Shrader, Jefferson C. Frisbee, and Paul D. Chantler Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, Morgantown, West Virginia; Division of Exercise Physiology, West Virginia University Health Sciences Center, Morgantown, West Virginia; Department of Surgery, West Virginia University Health Sciences Center, Morgantown, West Virginia; Department of Family Medicine, West Virginia University Health Sciences Center, Morgantown, West Virginia; Center for Basic and Translational Stroke Research, West Virginia University Health Sciences Center, Morgantown, West Virginia; and Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center, Morgantown, West Virginia
منابع مشابه
Oxidant stress and constrictor reactivity impair cerebral artery dilation in obese Zucker rats.
This study tested the hypothesis that evolution of the metabolic syndrome in obese Zucker rats (OZR) leads to impaired dilator reactivity of cerebral resistance arteries vs. responses determined in lean Zucker rats (LZR). Middle cerebral arteries (MCA) from 17-wk-old male LZR and OZR were isolated and cannulated with glass micropipettes. Vascular reactivity was assessed in response to challenge...
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متن کاملLow-flow vascular remodeling in the metabolic syndrome X.
Peripheral microvascular dysfunction is a common affliction in patients with the metabolic syndrome X. Previous studies have described a number of vascular impairments in vasomotor control in both human patients and animal models of syndrome X, but the net effect of these impairments on microvascular structure has not been examined. The goal of the current study was to test the hypothesis that ...
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Frisbee, Jefferson C. Reduced nitric oxide bioavailability contributes to skeletal muscle microvessel rarefaction in the metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 289: R307–R316, 2005. First published March 31, 2005; doi:10.1152/ajpregu.00114.2005.—This study tested the hypothesis that chronically elevated oxidant stress contributes to impaired active hyperemia in skeletal musc...
متن کاملProgression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats.
We investigated the progression of vascular dysfunction associated with the metabolic syndrome with and without hyperglycemia in lean, Zucker obese, and Zucker diabetic fatty (ZDF) rats. Responses of aorta and small coronary and mesenteric arteries were measured to endothelium-dependent and -independent vasodilators. Indices of oxidative stress were increased in serum from ZDF rats throughout t...
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